Clinicopathological analysis of invasive micropapillary carcinoma of the breast: 47 cases
10.3760/cma.j.issn.1674-6090.2019.04.015
- VernacularTitle:乳腺浸润性微乳头状癌47例临床病理分析
- Author:
Ying WANG
1
;
Yingchao ZHANG
;
Zhenyu WANG
;
Guodong CHEN
;
Jinxiang ZHANG
;
Jingwei XU
Author Information
1. 吉林大学第二医院乳腺外科
- Keywords:
Breast cancer;
Invasive micropapillary carcinoma;
Clinical pathological characteristics;
Lymph node metastasis
- From:
Chinese Journal of Endocrine Surgery
2019;13(4):328-332
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical pathological characteristics and the prognosis of the invasive micropapillary carcinoma (IMPC) of breast cancer.Methods The clinical pathological characteristics of 47 IMPC patients treated in the Second Hospital of Jilin University from Jan.2010 to Dec.2016 were retrospectively analyzed.A long term survival has been followed.Results 47 IMPC patients were all female.The median age was 56(34-76) years old.The median diameter of the tumor was 1.9(0.8-7.0) cm.The rate of axillary lymph node metastasis was 66.7％ (30/44),the median number of axillary lymph node metastasis was 9.5 (1-55),and the metastasis number of 1 to 3 accounted for 43.3％ (13/30),the metastasis number of 4 to 9 accounted for 6.7％ (2/30),and the metastasis number more than 10 accounted for 50％ (15/30).The lymphatic invasion rate was 40.2％(39/97),and the skin and (or) the nipple invasion rate was 15.6％(7/45).The positive rate of ER,PR,HER2,E-Cadherin was 95.7％(44/46),91.3％(42/46),10.5％(4/38),100％(40/40),respectively.The tumor cell growth index marked by Ki-67 was 1％-80％,and 78.3％ patients' tumor cell growth index marked by Ki-67 were more than 20％.Conclusions IMPC is a relatively rare special type of breast cancer,which typically occurs at middle-aged and old female.The expression of ER,PR,E-Cadherin is high and the expression of HER2 is low.It has strong ability and high positive rate of lymph node metastasis,lymphatic invasion,and poor prognosis.
