Predictive factors for postoperative hypocalcemia after reoperation of thyroid cancer
10.3760/cma.j.issn.1674-6090.2019.04.003
- VernacularTitle:再次甲状腺癌术后低钙血症的危险因素分析
- Author:
Liang CHEN
1
;
Fuqiang LI
;
Xiaojun XIE
;
Yibin SHEN
;
Feng ZHU
;
Liang HU
;
Qiwen HE
;
Yijun WU
Author Information
1. 浙江大学附属第一医院甲状腺疾病诊治中心 310003
- Keywords:
Thyroid cancer;
Reoperation;
Hypocalcemia;
Hypothyroidism
- From:
Chinese Journal of Endocrine Surgery
2019;13(4):273-277
- CountryChina
- Language:Chinese
-
Abstract:
Objective Hypothyroidism(HypoPT) is one of the most common complications of thyroid reoperation,and hypocalcemia caused by HypoPT is a difficult problem in clinical practice.This study aims to investigate the risk factors for hypoealcemia after reoperation of thyroid cancer.Methods Data of 106 patients who underwent reoperation for thyroid cancer from 2013 to 2018 were retrospectively analyzed.According to the parathyroid area involved in the reoperation,the reoperation was graded:low-risk group,intermediate-risk group and high-risk group.Parathyroid hormone(PTH) and total calcium(Ca) levels were monitored at 12 to 24 hours after surgery.The follow-up period was at least 6 months.The PTH cut-off values of postoperative hypocalcemia were analyzed by ROC curve.The chi-square test and logistic regression analysis were used to analyze the risk factors of postoperative hypocalcemia.Results The incidence of transient HypoPT after reoperation was 35％,and the permanent HypoPT was 1.9％.The grade of reoperation was positively correlated with postoperative HypoPT.The ROC curve showed that the PTH cut-off values of postoperative hypocalcemia was 15 pg/ml and area under curve(AUC) was 0.636(95％ CI:0.530-0.742,P＜0.017).Univariate and multivariate analysis showed that reoperation grade and postoperative PTH＜15 pg/ml were independent risk factors for postoperative hypocalcemia.Conclusion The grade of reoperation and postoperative PTH value ＜15 pg/ml can predict postoperative hypocalcemia.
