A meta-analysis on surgical treatment of chronic pancreatitis:duodenum-preserving pancreatic head resection versus pancreaticoduodenectomy
10.3760/cma.j.issn.1674-6090.2019.03.017
- VernacularTitle:保留十二指肠的胰头切除术与胰十二指肠切除术治疗慢性胰腺炎疗效的Meta分析
- Author:
Yonghui SUN
1
;
Xiaojing ZHANG
;
Hai LIN
;
Xinli GONG
;
Bingzheng YAN
;
Jiaqi XU
;
Qilong CHEN
Author Information
1. 新疆医科大学第一附属医院消化血管外科中心胰腺外科 830054
- Keywords:
Chronic pancreatitis;
Pancreaticoduodenectomy;
Duodenum-preserving pancreatic head resection;
Meta-analysis
- From:
Chinese Journal of Endocrine Surgery
2019;13(3):249-255
- CountryChina
- Language:Chinese
-
Abstract:
Objective To carry out a meta-analysis,in order to evaluate the effectiveness and safety of the duodenum-preserving pancreatic head resection (DPPHR) and pancreaticoduodenectomy (PD) or pylorus-preserving pancreaticoduodenectomy(PPPD) for surgical treatment of chronic pancreatitis.Methods Medline,EMBASE,Cochrane library and other medical databases were searched for the clinical trials (randomized controlled trials) of comparing DPPHR Versus PD/PPPD.A total of 5 clinical trials (8 references) met the inclusion criteria.The data were analyzed using the RevMan 5.3 software.Results The two methods don't have statistical differ ence in terms of operation time (P=0.007),postoperative morbidity (P=0.35) and mortality (P=0.18),pain relief(P=0.36),new onset of diabetes(P=0.11),exocrine insufficiency(P=0.18),short-term(P=0.14) and long-term(P=0.16) quality of life score,the length of hospital stay (P=0.69),and pancreatic fistula (P=0.78).Weight gain (P＜0.000 01) and occupational rehabilitation (P=0.03)were significantly improved in the DPPHR group.However,PD/PPPD group was associated with fewer readmission due to pancreatic diseases.Conclusions DPPHR offers more advantages with regard to the quality of life.However,it needs more high-quality clinical trials to verify the results.
