Effects of Geraniin on Modulating the Expression of Cbfα 1 Gene in Rabbit Osteoporotic Fracture
10.3969/j.issn.1003-4706.2018.08.001
- VernacularTitle:老鹳草素调控家兔骨质疏松性骨折关键基因Cbfα 1的表达
- Author:
Xiao-Chao ZHANG
1
;
Ren-Hua YANG
;
Ying SHEN
;
Hong-Yang HE
;
Jin-Ping ZHONG
;
Zhi-Qiang SHEN
;
Peng CHEN
Author Information
1. 昆明医科大学药学院暨云南省天然药物药理重点实验室
- Keywords:
Geraniin;
Osteoporotic fracture;
Corebinding factor α 1
- From:Journal of Kunming Medical University
2018;39(8):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the the effects of geraniin on modulating the mRNA expression of corebinding factor α 1 (Cbfα 1). Methods The m RNA expressions of Cbfα 1 were detected by real time fluorescence quantitative PCR. Results As compared with the sham group, the expressions of Cbfα 1 mRNA were markedly suppressed in the model group, 12 and 24 w after OPF (P < 0.05). Compared with the model group, geraniin significantly increased mRNA expressions of Cbfα 1. Conclusion Geraniin can upregulate Cbfα 1 gene expression and improve the treatment for OPF.