Research Progress of Gas6 with Type 2Diabetes Mellitus and Diabetic Complications
10.3969/j.issn.1003-4706.2018.03.024
- VernacularTitle:Gas6与2型糖尿病及其并发症的研究进展
- Author:
Xue-E DONG
1
;
Hui-Fang LI
Author Information
1. 昆明医科大学第一附属医院糖尿病科
- Keywords:
Growth arrest-specific 6;
Type 2 diabetes mellitus;
Obesity;
Insulin resistance;
Diabetic complications
- From:Journal of Kunming Medical University
2018;39(3):119-124
- CountryChina
- Language:Chinese
-
Abstract:
Growth arrest-specific 6, which is a member of the vitamin K-dependent protein family, is a ligand of TAM (Tyro3, Axl, Mer) belonging to the receptor tyrosine kinase family.Gas6/Axl signaling pathways are involved in pathophysiological processes of cell adhesion, migration, proliferation, apoptosis, platelet aggregation, vascular remodeling, inflammatory and immune responses. In recent years, studies found that Gas6/Axl signaling pathway, Gas6 level and the gene polymorphism of Gas6 were significantly associated with type 2 diabetes, obesity, insulin resistance and diabetic complications.This article reviews the correlation between Gas6 and type 2 diabetes and its complications
