Relationship between the Proportion of Tumor Infiltrating Lymphocytes in Tumor Mass and Postoperative Recurrence of Prostate Carcinoma
10.3969/j.issn.1003-4706.2018.03.012
- VernacularTitle:肿瘤组织内肿瘤侵润淋巴细胞和前列腺癌术后复发的关系
- Author:
Zhen RAN
1
;
Yun-Sha ZHU
;
Bing HAI
;
Jin-Song ZHANG
Author Information
1. 昆明市第二人民医院泌尿外科
- Keywords:
Prostate cancer;
Recurrence;
Tumor infiltrating lymphocytes
- From:Journal of Kunming Medical University
2018;39(3):62-66
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between proportion of Tumor infiltrating lymphocytes (TILs) in the prostate tumor mass and postoperative recurrence of prostate carcinoma in order to offer the theoretic as well as experimental basis for the prevention of postoperative recurrence in the prostate carcinoma.Methods The proportion of CD3+, CD8+, CD3+CD4+, CD3+CD8+ TILs cells of 81 PCa specimens underwent Radical prostatectomy were analyzed. The proportion of CD3+CD8+TILs in patients with recurrence of PCa within3 years after surgery (group A), within 35 years (group B) and without recurrence after 5 years (group C) was compared. Results The proportion of CD3+CD8+TILs was significantly lower in group A than that of in group B and C (P＜0.05), meanwhile, the proportion of CD3+CD8+TILs were significantly higher in group C than that in group A and B (P＜0.05), while the proportion of CD3+, CD8+, CD3+CD4+ in three groups had no significant difference (P＞0.05). Conclusion The proportion of CD3+CD8+TILs presented in the PCa specimen mass is relative to the postoperative recurrence of prostate cancer, which might be a biomarker for the surveillance of postoperative recurrence of PCa.
