Research on Preparation and in Vitro Release of pH Sensitive Gel for Eye Cornea of Salvianolic Acid B
10.3969/j.issn.1003-4706.2018.03.005
- VernacularTitle:丹酚酸B原位眼用凝胶剂的制备及体外释放
- Author:
Jin KE
1
;
Zi-Wei ZHAO
;
Shan-Shan LI
;
Pei-Fang ZHU
;
An-Guo HOU
Author Information
1. 云南中医学院中药学院
- Keywords:
Alvianolic acid B;
pH sensitive gel for eye cornea;
Corneal permeability;
In-vitro release
- From:
Journal of Kunming Medical University
2018;39(3):23-30
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare pH sensitive gel for eye cornea of salvianolic acid B and accomplish in vitro release study. Me thods We used corneal permeability, eye irritation in rabbits, hydration of the cornea, viscosity, gel capacity, transparency, liquidity as index, to select pH sensitive gel matrix composition. Re s ults The gel composition was: 0.5％ of salvianolic acid B, 0.14％ Carbomer, 0.3％ HPMC, 0.05％ Azone, 0.1％ ethylparaben and 0.2％ Vc. The corneal hydration level was 77.32±1.88.The gel released 27.21％ drug in 15 min, and released 97.44％ drug in 6 h. By research of corneal permeability, the cumulative release of gel was bigger than the one of saline (P＜0.05). Conclus ions The selection of the gel matrix prescription is reasonable in design, simple in process, not harsh to eyes, and can prolong the retention time of drug in corneas and improve the corneal penetration.
