Clinical study on treatment of chronic atrophic gastritis with Weisu granule combined with quadruple therapy
10.3760/cma.j.issn.1673-4246.2019.07.004
- VernacularTitle:胃苏颗粒联合四联疗法治疗慢性萎缩性胃炎临床研究
- Author:
Qiu LIANG
1
;
Peng LAN
;
Chuang YANG
;
Weijun ZHU
;
Qingyun KONG
Author Information
1. 江苏省连云港市灌南县第一人民医院消化科 222500
- Keywords:
Gastritis,atrophic;
Weisu cranule;
Quadruple therapy;
Therapies,investigational
- From:
International Journal of Traditional Chinese Medicine
2019;41(7):688-691
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of Weisu granule combined with conventional therapy in treatment of chronic atrophic gastritis (CAG). Methods A total of 99 CAG patients who met the inclusion criteria were randomly divided into control group (49 cases) and observation group (50 cases) according to random number table method. The control group was treated with quadruple therapy, while the observation group was treated with Weisu granule on the basis of the control group. Both groups were treated for 90 days. Interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α) were detected by ELISA. The scores of TCM symptoms between the two groups before and after treatment were compared. Adverse reactions during treatment were observed and recorded. The eradication rate of H.pylori was measured by 14C urea breath test, and the clinical efficacy was evaluated. Results The total effective rate was 92.0% (46/50) in the observation group and 73.5% (36/49) in the control group. There were significant differences between the two groups (χ2=5.975, P=0.015). After treatment, the level of serum IL-6, hs-CRP and TNF-α in the observation group was significantly lower than those in the control group (t=7.112, 7.753, 9.310, respectively, all P<0.01). After treatment, the scores of symptoms such as abdominal distension and pain, emotional disturbance, hypochondrium pain and belching in both groups decreased (P<0.01), and those in the observation group was significantly lower than those in the control group (t=12.892, 12.451, 10.596, respectively, P<0.01). The eradication rate of H.pylori was 90.0% (45/50) in the observation group and 24.5% (12/49) in the control group. There was a significant difference between the two groups (χ2=43.381, P<0.01). Conclusions The Weisu granule combined with quadruple therapy has a definite theraputic effect. It can improve the clinical symptoms of patients, improve the clearance rate of H.pylori, and alleviate inflammation.
