Efficacy of Yiqi-Tuomin decoction combined with triamcinolone acetonide nasal spray on allergic rhinitis and its effect on Th1/Th2 balance
10.3760/cma.j.issn.1673-4246.2019.06.004
- VernacularTitle:益气脱敏汤结合曲安奈德鼻喷雾剂对变应性鼻炎Th1/Th2平衡的影响
- Author:
Shisi WANG
1
;
Jiyan XIA
Author Information
1. 广州中医药大学第二临床医学院 510155
- Keywords:
Rhinitis,allergic;
Th1-Th2 balance;
Yiqi-Tuomin decoction;
Triamcinolone acetonide nasal spray;
Therapies,investigational
- From:
International Journal of Traditional Chinese Medicine
2019;41(6):565-568
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Yiqi-Tuomin decoction combined with triamcinolone acetonide nasal spray on Th1/Th2 balance in allergic rhinitis (AR) and to observe the clinical efficacy.Methods A total of 100 patients who met the inclusion criteria were divided into two groups by random number table method,50 in each group.The control group was treated with triamcinolone acetonide nasal spray.The observation group was given Yiqi-Tuomin decoction on the basis of the control group.Both groups were treated for 4 weeks and followed up for 3 months.Clinical symptom score was performed before and after treatment.The serum level of interferon-γ (IFN-γ) and IL-4 was detected by ELISA,and the ratio of IFN-γ/IL-4 was calculated.The adverse reaction and recurrence rate during treatment was observed and recorded,and the clinical efficacy was evaluated.Results The total effective rate was 94.0％ (47/50) in the observation group and 80.0％ (40/50) in the control group.There was significant difference between the two groups (x2=4.332,P=0.037).After treatment,the serum IFN-γ (95.15 ± 18.49 ng/L vs.83.85 ± 16.20 ng/L,t=3.250) and the ratio of IFN-γ/IL-4 (1.35 ± 0.21 vs.0.93 ± 0.19,t=5.878) significantly increased (P＜0.01),while serum level of IL-4 (71.14 ± 14.15 ng/L vs.89.8 6 ± 17.52 ng/L,t=10.487) significantly decreased in the observation group (P＜0.01).After treatment,the score of nasal obstruction,rhinocnesmus,sneezing and nasal discharge in the observation group were significantly lower than those in the control group (t=11.229,8.921,8.253,10.464,respectively,all Ps＜0.01).Conclusions The Yiqi-Tuomin decoction combined with triamcinolone acetonide nasal spray can significantly improve the clinical symptoms of AR patients,correct the imbalance of Th1/Th2 ratio and improve the immunity of the body.
