Clinical application of exosomal miRNA as biomarker in breast cancer
10.3760/cma.j.issn.1673-422X.2019.07.007
- VernacularTitle:外泌体miRNA作为乳腺癌生物标志物的临床应用
- Author:
Lixia CAO
1
;
Zhendong SHI
;
Jingjing LIU
;
Jin ZHANG
Author Information
1. 天津医科大学肿瘤医院乳腺三科 国家肿瘤临床医学研究中心 天津市"肿瘤防治"重点实验室 天津市恶性肿瘤临床医学研究中心 300060
- Keywords:
Breast neoplasms;
Exosomes;
MicroRNAs;
Biomarker
- From:
Journal of International Oncology
2019;46(7):423-426
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNA (miRNA)has a tumor-specific expression profile and plays an important role in the occurrence and progression of tumors. It is protected from RNase in body fluids through the inclusion of exo-somes and translocates genetic information horizontally between breast cancer cells. Recent studies on exosome miRNA have found that it is closely related to the occurrence,diagnosis,treatment and prognosis of breast cancer. The in-depth study in this field can provide theoretical basis for the clinical application of exosome miRNA as a biomarker for breast cancer.
