Effect of ubiquitin-specific protease on radiosensitivity of tumor
10.3760/cma.j.issn.1673-422X.2019.07.006
- VernacularTitle:泛素特异性蛋白酶对肿瘤放疗敏感性的影响
- Author:
Qifen ZHOU
1
;
Chunlin WU
Author Information
1. 福建医科大学基础医学院
- Keywords:
Neoplasms;
Radiation tolerance;
Ubiquitin specific proteases
- From:
Journal of International Oncology
2019;46(7):420-422
- CountryChina
- Language:Chinese
-
Abstract:
Ubiquitin-specific protease is a member of the deubiquitinating enzyme family,which can reverse the ubiquitination of proteins and stabilize proteins. It affects radiosensitivity of tumor by regulating DNA damage,cell cycle,nuclear factor-κB signaling pathway,Nrf2-Keap1 signaling pathway and oncogene c-myc. It is expected to become a new target for tumor radiotherapy sensitization.
