Mechanism study of cancer-associated fibroblasts and clinical application in breast cancer
10.3760/cma.j.issn.1673-422X.2019.06.009
- VernacularTitle:肿瘤相关成纤维细胞的机制研究及其在乳腺癌中的临床应用
- Author:
Jiahui YE
1
;
Weijie ZHANG
Author Information
1. 南京大学南京大学医学院附属鼓楼医院普外科 210008
- Keywords:
Cancer-associated fibroblasts;
Breast neoplasms;
Tumor microenvironment;
Biomarkers;
Prognosis
- From:
Journal of International Oncology
2019;46(6):358-361
- CountryChina
- Language:Chinese
-
Abstract:
The occurrence and development of breast cancer is a complex process which referring to multi-factor interaction.During this process,cancer-associated fibroblasts (CAFs) secrect various growth factors and cytokines to promote the tumor progression,angiogenesis,metastasis,drug resistance.Meanwhile,it can also judge the prognosis of patients through the expression of CAFs.CAFs may offer a new therapeutic strategy against breast cancer.
