Profile of gene mutations and targeted treatment of brain metastases in breast cancer
10.3760/cma.j.issn.1673-422X.2019.06.008
- VernacularTitle:乳腺癌脑转移的基因突变特征及靶向治疗
- Author:
Zongbi YI
1
;
Fei MA
;
Binghe XU
Author Information
1. 国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院肿瘤内科
- Keywords:
Breast neoplasms;
Brain metastasis;
Mutation;
Targeted therapy
- From:
Journal of International Oncology
2019;46(6):354-357
- CountryChina
- Language:Chinese
-
Abstract:
Brain metastasis (BM) is considered one of the major causes of mortality in breast cancer patients.BM develops more frequently in triple-negative breast cancer and human epidermal growth factor receptor 2 (HER2)-positive breast cancers,while the incidence of BM in hormone receptor positive is much lower.Mutations and expression of BM of breast cancer are differ from their primay tumors.Importantly,some therapeutic actionable mutations can be present in the BM while not in the primary tumors.Current targeted therapeutics in BM of breast cancers are limited,and drugs used have proven effects on the primary tumors but lack specificity for the BM.The identification of genomic and expressional alterations specific to BM are crucial to the development of BM specific targeted therapies.
