Lysine demethylase 6 and tumors
10.3760/cma.j.issn.1673-422X.2019.05.008
- VernacularTitle:赖氨酸去甲基化酶6与肿瘤
- Author:
Longlong LI
1
;
Kongwang HU
Author Information
1. 安徽医科大学第一附属医院胃肠外科
- Keywords:
Neoplasms;
Histone demethylase;
Lysine specific demethylase 6
- From:
Journal of International Oncology
2019;46(5):289-294
- CountryChina
- Language:Chinese
-
Abstract:
Lysine demethylase 6 (KDM6) is involved in the demethylation regulation of histone H3 as an important modification enzyme in epigenetic modification,and plays an important role in embryonic development,inflammation and disease development.Current researches indicate that KDM6 is involved in the occurrence and development of various tumors (pancreatic cancer,colon cancer,gastric cancer,breast cancer,bladder cancer,etc.),affects proliferation,metastasis,prognosis and chemotherapy resistance of tumors,and plays different roles due to different tumor backgrounds.
