Advances of homeobox gene MEOX1 in tumors
10.3760/cma.j.issn.1673-422X.2019.05.005
- VernacularTitle:同源盒基因MEOX1在肿瘤中的研究进展
- Author:
Yuan ZHANG
1
;
Lichao SUN
Author Information
1. 国家癌症中心 国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院分子肿瘤学国家重点实验室
- Keywords:
Genes,homeobox;
Neoplasms;
MEOX1
- From:
Journal of International Oncology
2019;46(5):278-280
- CountryChina
- Language:Chinese
-
Abstract:
As a homeobox transcription factor,MEOX1 can regulate the target genes by binding the specific DNA sequence.MEOX1 not only plays essential roles in cell proliferation,migration and differentiation,but also participates in the formation of skeleton,muscle and blood vessel during embryonic development.Recent studies demonstrate that MEOX1 is over-expressed in breast cancer,lung cancer,ovarian cancer and prostate cancer tissues,which is closely associated with lymph node metastasis and poor prognosis in patients with cancer.Furthermore,MEOX1 can regulate the proliferation and migration of cancer cells,which suggests that it plays an important role in the occurrence and development of tumors.
