Expression and role of Hippo signaling pathway in non-small cell lung cancer
10.3760/cma.j.issn.1673-422X.2019.04.010
- VernacularTitle:Hippo信号通路及其在非小细胞肺癌中的表达和作用
- Author:
Zhao WANG
1
;
Yingnan WANG
;
Jixiang NI
;
Jing ZHU
Author Information
1. 三峡大学人民医院 湖北省宜昌市第一人民医院呼吸与危重症医学科 443000
- Keywords:
Carcinoma;
non-small-cell lung;
Gene expression;
Hippo signaling pathway;
Targeted therapy
- From:
Journal of International Oncology
2019;46(4):239-242
- CountryChina
- Language:Chinese
-
Abstract:
Hippo signaling pathway plays an important role in the growth and regeneration of animal organs. Studies have shown that the misexpression of Hippo signaling pathway composed of yes-associated protein and trascriptional co-activator with PDZ-binding motif is involved in the development of non-small cell lung cancer(NSCLC)and has synergistic effect with mutant p53. In addition,its overexpression leads to drug resistance in lung cancer treatment and inhibition of its expression may benefit cancer patients. The expression and role of Hippo signaling pathway in NSCLC are described in detail,which is expected to provide a new direction for targeted therapy of lung cancer.
