Regulating effect of microRNAs in lung cancer stem cells
10.3760/cma.j.issn.1673-422X.2019.04.008
- VernacularTitle:微小RNA在肺癌干细胞中的调控作用
- Author:
Guoli ZHAO
1
,
2
;
Hengyao LIU
;
Yueying ZHANG
Author Information
1. 济南大学 山东省医学科学院医学与生命科学学院 250200
2. 山东省医学科学院基础医学研究所病理学与病理生理学研究室
- Keywords:
MicroRNAs;
Lung neoplasms;
Tumor stem cells
- From:
Journal of International Oncology
2019;46(4):231-234
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer stem cells play an important role in chemoresistance and invasion and metastasis of lung cancer. Increasing evidence sustains that microRNAs(miRNAs)play a major role in regulating tumor angiogenesis,drug resistance and metastasis. Cancer stem cells are considered to be one of the reasons leading to cancer recurrence,metasta-sis and resistance to chemotherapy,therefore better understanding how miRNAs regulate gene expression in lung cancer stem cells will help identify cancer biomarkers and new therapeutic targets,and will help to develop better treatment strate-gies for lung cancer.
