Functional mechanism of malate dehydrogenase 2 in tumors
10.3760/cma.j.issn.1673-422X.2019.03.010
- VernacularTitle:苹果酸脱氢酶2在肿瘤中的作用机制
- Author:
Ying WU
1
;
Baixue FU
;
Lu DAI
;
Jun HUANG
;
Yibin TENG
;
Linlin LI
;
Jingwen ZHANG
;
Yuhong HUANG
Author Information
1. 大连医科大学基础医学院病理教研室 116044
- Keywords:
Oxidoreductases;
Neoplasms;
Malate dehydrogenase 2
- From:
Journal of International Oncology
2019;46(3):178-180
- CountryChina
- Language:Chinese
-
Abstract:
The role of malate dehydrogenase 2 (MDH2) in tumors is double-sided,it has a cancerpromoting effect in some tumors and an inhibitory effect in other tumors.The function of MDH2 is related to energy metabolism,tumor resistance and its pseudo hypoxia.MDH2 plays an important role in the occurrence,development,invasion and metastasis of tumors.An in-depth understanding of the functional mechanism of MDH2 in tumors can provide new molecular targets for tumor intervention in the clinic.
