Roles of AGGF1 in tumor and its regulatory mechanisms
10.3760/cma.j.issn.1673-422X.2019.03.007
- VernacularTitle:AGGF1在肿瘤中的作用及其调控机制
- Author:
Xiabo SHEN
1
;
Yan LI
;
Wei WANG
Author Information
1. 安徽医科大学附属安徽省立医院肿瘤内科
- Keywords:
Neoplasms;
Neovascularization,pathologic;
DNA repair;
Autophagy;
AGGF1
- From:
Journal of International Oncology
2019;46(3):166-169
- CountryChina
- Language:Chinese
-
Abstract:
Angiogenic factor with G and FHA domain 1 (AGGF1) is an identified angiogenic factor in recent years,which is highly expressed in vascular endothelial cells and exhibits the same function as vascular endothelial growth factor,and can promote angiogenesis.Recently,it has been found that AGGF1 is highly expressed in various tumors such as liver cancer,leukemia,glioma and gastric cancer.Based on its participation in the regulation of tumor angiogenesis,DNA repair and autophagy,tumors with high expression of AGGF1 are prone to drug resistance and metastasis,and the survival and prognosis of patients are worse.Deep understanding of the roles of AGGF1 in tumor angiogenesis and its specific molecular mechanisms will provide new strategies for anti-tumor angiogenesis therapy in the future.
