Progress in the relationship between zinc metabolism and esophageal cancer
10.3760/cma.j.issn.1673-4203.2019.08.015
- VernacularTitle:锌代谢与食管癌关系的研究进展
- Author:
Yaohui SUN
1
;
Yi LI
;
Fei WANG
;
Linyou ZHANG
Author Information
1. 哈尔滨医科大学附属第二医院胸外科 150001
- Keywords:
Esophageal neoplasms;
MicroRNAs;
Ion channels;
Zinc finger protein;
Zinc metabolism;
Inflammation
- From:
International Journal of Surgery
2019;46(8):567-571
- CountryChina
- Language:Chinese
-
Abstract:
Esophageal cancer is one of the common malignant tumors in China.Although it is currently treated by multidisciplinary treatment,esophageal cancer's prognosis is still poor.The occurrence of esophageal cancer is closely related to the metabolism of trace element zinc.Zinc deficiency can induce the development of esophageal cancer by inducing inflammatory reaction and microRNAs imbalance.Zinc ion can play an important role in esophageal cancer by regulating the activity of ion channel.The formed zinc finger protein can function as an oncogene or a tumor suppressor gene in esophageal cancer.Zinc metabolism is accompanied by complex biological changes in the pathogenesis of esophageal cancer,and multiple mechanisms interact and are closely linked.The article reviews the research results of recent years on the mechanism of zinc deficiency,zinc ion-regulated ion channel and zinc finger protein in the development of esophageal cancer.
