Breath acetone: trends in techniques and its potential clinical applications in diabetes management
10.3760/cma.j.issn.1673-4181.2019.03.009
- VernacularTitle:呼吸丙酮用于糖尿病监管的研究进展及临床应用前景
- Author:
Qingyuan LI
1
;
Meixiu SUN
;
Chuji WANG
;
Yingxin LI
Author Information
1. 中国医学科学院 北京协和医学院生物医学工程研究所
- Keywords:
Diabetes;
Acetone;
Breath analysis;
Biomarkers;
Cavity ring-down spectroscopy
- From:
International Journal of Biomedical Engineering
2019;42(3):231-238
- CountryChina
- Language:Chinese
-
Abstract:
Human exhaled gases contain thousands of trace amounts of trace volatile organic compounds (VOCs), some of which are endogenous substance and can be detected as potential biomarkers for disease. Acetone, the second highest VOCs in human exhaled gases, has been widely used in non-invasive diagnosis and monitoring of diabetes. At present, more than 30 independent studies have been undertaken on the range of breath acetone concentration and its influencing factors, and the quantitative relationship between blood glucose and glycosylated hemoglobin in diabetic patients. However, there are still many challenges in the application of breath acetone as a clinical regulatory parameter for diabetes. In this paper, the research status and progress in the breath acetone and analysis method were reviewed, and the existing problems in diabetes diagnosis and monitoring were discussed. Besides, the future development prospects were analyzed with the present technical level.
