Role of oligodendrocytes in ischemic white matter injury: cell-cell interaction
10.3760/cma.j.issn.1673-4165.2019.06.014
- VernacularTitle:少突胶质细胞在缺血性白质损伤中的作用:细胞-细胞相互作用
- Author:
Xi ZHANG
1
;
Xiang CAO
;
Yun XU
Author Information
1. 南京大学医学院附属鼓楼医院神经内科 210008
- Keywords:
Brain ischemia;
White matter;
Oligodendroglia
- From:
International Journal of Cerebrovascular Diseases
2019;27(6):471-476
- CountryChina
- Language:Chinese
-
Abstract:
Oligodendrocytes are the major glial cells in the white matter of brain. Under normal circumstances, they form myelin sheaths around axons, which are conducive to rapid nerve conduction.After cerebral ischemia, the death of oligodendrocytes increases, leading to white matter dysfunction. White matter repair is associated with the ability of proliferation and mature differentiation of oligodendrocyte precursor cells. However, oligodendrocyte proliferation and differentiation may not be the only mechanism of white matter damage repair. Existing studies have shown that white matter repair requires synergistic action among neurons, glial cells and vascular endothelial cells in the whole neurovascular unit.
