Role of inflammation in cognitive impairment induced by chronic cerebral hypoperfusion and its mechanism
10.3760/cma.j.issn.1673-4165.2019.06.013
- VernacularTitle:炎症在慢性脑低灌注引起的认知损害中的作用及其机制
- Author:
Xi PENG
1
;
Yang HU
;
Qian WANG
;
Wenying ZOU
;
Zhuoyou CHEN
Author Information
1. 南京医科大学附属常州第二人民医院神经内科
- Keywords:
Brain ischemia;
Cognition disorders;
Inflammation;
White matter;
Blood-brain barrier
- From:
International Journal of Cerebrovascular Diseases
2019;27(6):467-470
- CountryChina
- Language:Chinese
-
Abstract:
Chronic cerebral hypoperfusion (CCH) is a common pathological change of central nervous system diseases and is closely associated with cognitive impairment. A number of studies have shown that inflammation is involved in the pathogenesis and progression of CCH-induced cognitive impairment. In the condition of CCH, the activation of inflammatory response in the brain can lead to a variety of pathological injuries, such as white matter lesions, blood-brain barrier destruction, degeneration and necrosis of hippocampal neurons, etc. Therefore, inhibition of inflammatory response is expected to provide a new therapeutic target for CCH-induced cognitive impairment. This article reviews the mechanism of inflammation in CCH-induced cognitive impairment.
