Lectin-like oxidized low-density lipoprotein receptor-1 and ischemic stroke
10.3760/cma.j.issn.1673-4165.2019.05.012
- VernacularTitle:凝集素样氧化型低密度脂蛋白受体-1与缺血性卒中
- Author:
Xiao PENG
1
;
Xiangyang ZHU
;
Xin GE
;
Mengmeng LI
;
Dongmei ZHANG
Author Information
1. 南通大学第二附属医院临床医学研究中心 226001
- Keywords:
Stroke;
Brain ischemia;
Scavenger receptors,class E;
Receptors,oxidized LDL;
Risk factors
- From:
International Journal of Cerebrovascular Diseases
2019;27(5):384-389
- CountryChina
- Language:Chinese
-
Abstract:
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a member of C-type lectin-like receptor family.It can recognize many ligands and is the main receptor of oxidized low-density lipoprotein for inducing vascular endothelial dysfunction.Early studies focused on the role of LOX-1 in atherosclerosis and diabetes mellitus.Recent studies have shown that LOX-1 is closely associated with ischemic stroke.This article reviews the biological characteristics of LOX-1 and its association with ischemic stroke.
