Platelet-associated microRNA and platelet reactivity in patients with ischemic stroke
10.3760/cma.j.issn.1673-4165.2019.05.011
- VernacularTitle:血小板相关微RNA与缺血性卒中患者血小板反应性
- Author:
Xiaoshuang XIA
1
;
Xin LI
Author Information
1. 天津医科大学第二医院神经内科 300211
- Keywords:
Stroke;
Brain ischemia;
Platelets;
MicroRNAs;
Platelet activation
- From:
International Journal of Cerebrovascular Diseases
2019;27(5):380-383
- CountryChina
- Language:Chinese
-
Abstract:
Platelets contain a large number of microRNAs (miRNAs),for example,miR-223,miR-126,and miR-191 are highly expressed in platelets,affecting platelet reactivity through different targets.Platelet-associated miRNAs are involved in platelet activation and are associated with the onset risk and outcome of ischemic stroke,and may be a novel marker for early diagnosis and prognostic evaluation of ischemic stroke and provide new therapeutic targets for ischemic stroke.Moreover,platelet-associated miRNAs may play a regulatory role in platelet function and gene expression,and have potential role in evaluating the efficacy of antiplatelet drugs,especially in screening high on-treatment platelet reactivity and high-risk patients as early as possible to guide individualized treatment of antiplatelet drugs.
