Correlation between heme oxygenase-1 gene rs2071746 polymorphism and long-term outcome in patients with ischemic stroke
10.3760/cma.j.issn.1673-4165.2019.05.005
- VernacularTitle:血红素加氧酶1基因rs2071746多态性与缺血性卒中患者远期转归的相关性
- Author:
Liping CAO
1
;
Linfeng ZHU
;
Huajie LI
;
Lei JI
;
Chunxian YUE
;
Jian WU
;
Shiying SHENG
;
Xuegan LIAN
Author Information
1. 苏州大学附属第三医院神经内科
- Keywords:
Stroke;
Brain ischemia;
Heme oxygenase-1;
Polymorphism,genetic;
Prognosis;
Risk factors
- From:
International Journal of Cerebrovascular Diseases
2019;27(5):343-347
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between heme oxygenase-1 (HO-1) gene rs2071746 polymorphism and long-term clinical outcome in patients with ischemic stroke.Methods Between July 2015 and June 2017,consecutive patients with acute ischemic stroke admitted to the Department of Neurology,the Third Affiliated Hospital of Soochow University were enrolled prospectively.TOAST classification was performed for all patients.Genotyping of the HO-1 gene rs2071746 polymorphism was performed using a modified multiplex ligase detection reaction technique.The patients were followed up.The primary endpoint events included ischemic stroke,vascular death,and myocardial infarction.Multivariate Cox proportional hazard regression model was used to analyze the independent influencing factors for primary endpoint events.Results A total of 1 698 patients with successful genotyping and follow-up information were enrolled.Genotyping showed that the frequency of rs2071746 A allelewas 44.91％.They were followed up for 15.21 ± 7.39 months,and 168 patients (9.89％) had primary endpoint events.The incidence of primary endpoint events in A allele carriers was significantly lower than that in non-A allele carriers (8.80％ vs.12.40％;P =0.018).Multivariate Cox proportional risk regression model showed that after adjusting for age,gender,hypertension,diabetes mellitus,smoking,alcohol consumption,and genotype,A allele was an independent protective factor for primary endpoint events in patients with acute ischemic stroke (hazard risk [HR] 0.693,95％ confidence interval [CI]0.506-0.949;P=0.022).Subgroup analysis showed that carrying the A allele was an independent protective factor for primary endpoint events in patients with large atherosclerotic stroke (HR 0.651,95％ CI 0.425-0.997;P=0.048),while rs2071746 polymorphism was not associated with long-term outcome in other etiological subtypes.Conclusion The HO-1 gene rs2071746 A allele may be a protective factor for the long-term outcome in patients with acute ischemic stroke and large atherosclerotic stroke.
