Progress in the relationship between urokinase plasminogen activator receptor and its soluble form and renal disease
10.3760/cma.j.issn.1673-4408.2019.08.008
- VernacularTitle:尿激酶型纤溶酶原激活物受体及其可溶形式与肾脏病关系的研究进展
- Author:
Yaoyue ZHANG
1
Author Information
1. 山西医科大学第一临床医学院
- Keywords:
Urokinase-type plasminogen activator receptor;
Soluble urokinase-type plasminogen activator receptor;
Glomerular disease
- From:
International Journal of Pediatrics
2019;46(8):571-574
- CountryChina
- Language:Chinese
-
Abstract:
Glomerular disease refers to a class of diseases in which the lesions are mainly located in the glomerulus,and the clinical manifestations are mainly hematuria,proteinuria,edema,hypertension and renal dysfunction.In recent years,it has been found that the urokinase-type plasminogen activator (uPA) of the plasminogen activator family,urokinase-type plasminogen activator receptor (uPAR) and its soluble form have been up-regulated in the pathogenesis of certain glomerular diseases.The combination with integrin affects signaling pathways and changes the morphology and function of podocytes to promote disease progression.In this paper,the relevant research progress is summarized as follows.
