Research progress in hypogonadism of patients with β-thalassemia major
10.3760/cma.j.issn.1673-4408.2019.06.010
- VernacularTitle:重型β-地中海贫血患者性腺功能低下症的研究进展
- Author:
Zhuannan JIANG
1
Author Information
1. 中山大学孙逸仙纪念医院儿科
- Keywords:
β-thalassemia major;
Hypogonadism;
Iron overload
- From:
International Journal of Pediatrics
2019;46(6):424-426
- CountryChina
- Language:Chinese
-
Abstract:
Hypogonadism is one of the most common endocrine complications in patients with β-thalassemia major (β-TM).It can be clinically characterized by pubertal developmental delay,primary or secondary amenorrhea infertility that would significantly compromises the quality of life of patients with β-TM.Its pathogenesis is complex and may be related to long-term anemia,iron overload,decreased leptin levels,chronic liver disease,transplant pretreatment drugs and so on.Regular monitoring and active intervention are crucial for promoting adolescent development,sexual function maturation and retention of fertility in β-TM patients.However,there is no relevant guidelines and consensus in our country to guide clinicians on the followup of gonadal function in β-TM patients.This review aims to summarize the research progress in hypogonadism of patients with β-TM in order to improve the level of prevention and treatment.
