Progress of myostatin on duchenne muscular dystrophy
10.3760/cma.j.issn.1673-4408.2019.05.012
- VernacularTitle:Myostatin在杜氏肌营养不良疾病中的研究进展
- Author:
Shuangshuang HAN
1
Author Information
1. 中国药科大学江苏省新药筛选中心重点实验室
- Keywords:
Duchenne muscular dystrophy;
Myostatin;
Skeletal muscle;
Dystrophin
- From:
International Journal of Pediatrics
2019;46(5):356-359
- CountryChina
- Language:Chinese
-
Abstract:
Duchenne muscular dystrophy (DMD) is a severe muscular genetic disorder,which is caused by a mutation in the DMD gene encoding the dystrophin protein.The clinical manifestation of DMD is the progressive muscular dystrophy.Myostatin is a negative regulator of skeletal muscle growth and development.In recent years,it has received extensive attention in the treatment of muscle diseases.This review focuses on the structural and activity of myostatin,its regulation of skeletal muscle growth and noval approaches to Myostatin inhibitor in the treatment of DMD.
