Progress of epigenetics in acute myeloid leukemia
10.3760/cma.j.issn.1009-9921.2019.08.013
- VernacularTitle:急性髓系白血病中表观遗传学的研究进展
- Author:
Liman LIN
1
;
Dengju LI
Author Information
1. 华中科技大学同济医学院附属同济医院血液内科
- Keywords:
Leukemia,myeloid,acute;
Epigenetic,mutation;
Immunohistochemistry
- From:
Journal of Leukemia & Lymphoma
2019;28(8):505-508
- CountryChina
- Language:Chinese
-
Abstract:
Acute myeloid leukemia (AML) is considered to be an irreversible change of gene function caused by certain genetic changes, resulting in abnormal proliferation, differentiation disorder, and abnormal apoptosis of leukemia cells, leading to the occurrence and development of leukemia. Epigenetics refers to the change of heritable gene expression but the gene does not change in sequence. A large number of studies have shown that the pathogenesis of AML is closely related to the regulation of epigenetics. The regulation of epigenetic modification in the cellular metabolism, immune microenvironment and immune response of AML has been received increasing attention. This review will describe the regulation of epigenetics in the cellular metabolism, immune microenvironment and immune response of AML and the advances in the targeted intervention measures.
