Myelodysplastic syndromes combined with mature plasmacytoid dendritic cells proliferation: report of one case and review of literature
10.3760/cma.j.issn.1009﹣9921.2019.07.004
- VernacularTitle:伴成熟浆细胞样树突细胞增生的骨髓增生异常综合征一例并文献复习
- Author:
Jing LIU
1
;
Hongmin YAN
;
Ling ZHU
;
Xiaoli ZHENG
;
Li DING
;
Dongmei HAN
;
Xitong TAN
;
Hengxiang WANG
;
Mei XUE
Author Information
1. 空军特色医学中心(原空军总医院)血液科
- Keywords:
Myelodysplastic syndromes;
Plasmacytoid dendritic cells;
Diagnosis;
Treatment
- From:
Journal of Leukemia & Lymphoma
2019;28(7):401-403
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical features, diagnosis, treatment and prognosis of myelodysplastic syndromes (MDS) with mature plasmacytoid dendritic cells (PDC) proliferation. Methods The clinical data of one case of MDS with excess blasts (EB)﹣1 with mature PDC proliferation in Air Force Medical Center was retrospectively analyzed, and the literature was reviewed. Results The patient′s physical examination revealed anemia and thrombocytopenia. Bone marrow smears showed 0.064 of myeloblasts and 0.152 of dendritic cells. Immunophenotyping showed two groups of abnormal proliferation cells, namely, myeloblasts and mature PDC. Decitabine treatment was given, and the red blood cells and platelets were infused intermittently. The condition of patient was basically stable. Conclusions MDS with mature PDC proliferation is extremely rare. No special clinical manifestations are found, and the diagnosis is based on bone marrow cytology and immunophenotyping. There is no standard regimen for treatment of MDS with mature PDC proliferation, and the prognosis depends on the progression of MDS.
