Progress of detection techniques of Philadelphia chromosome鄄like acute lymphoblastic leukemia
10.3760/cma.j.issn.1009_9921.2019.04.017
- VernacularTitle:费城染色体样急性淋巴细胞白血病的检测技术进展
- Author:
Xiaojia FENG
1
;
Bin JIANG
Author Information
1. 北京大学国际医院血液科 102206
- Keywords:
Philadelphia chromosome_like acute lymphoblastic leukemia;
Flow cytometry;
Gene expression profiling;
Diagnosis;
Prognosis
- From:
Journal of Leukemia & Lymphoma
2019;28(4):254-256
- CountryChina
- Language:Chinese
-
Abstract:
Philadelphia chromosome_like acute lymphoblastic leukemia (Ph_like ALL) characterized by a high rate of relapse and poor outcome of chemotherapy and prognosis, also known as BCR_ABL1_like ALL, is a kind of B_ALL subtypes, a pattern of gene expression profiling similar to that of BCR_ABL1 ALL positive but lacking BCR_ABL1 fusion gene. With the better understanding of gene expression profiling, the World Health Organization (WHO) (2016) has regarded Ph_like ALL as an independent subtype of B_ALL. The diagnosis highly depends on the laboratory techniques, and a wide range of diagnostic methods can be applied in clinic, which may bring a big challenge for the clinicians. This paper reviews the various laboratory techniques of Ph_like ALL and subtype group analysis, to provide a basis for target therapy and to improve the prognosis.
