Significance of WT1 gene detection in the prognosis of acute myeloid leukemia patients with normal karyotype after hematopoietic stem cell transplantation
10.3760/cma.j.issn.1009_9921.2019.04.002
- VernacularTitle:WT1基因水平监测对造血干细胞移植后正常核型急性髓系白血病患者预后的意义
- Author:
Yanjun SUN
1
;
Yang XU
;
Jiannong CEN
;
Huiying QIU
;
Suning CHEN
;
Aining SUN
;
Depei WU
Author Information
1. 苏州卫生职业技术学院临床医学院 215006
- Keywords:
Gene,WT1;
Hematopoietic stem cell transplantation;
Leukemia,myeloid,acute;
Prognosis
- From:
Journal of Leukemia & Lymphoma
2019;28(4):198-204
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the monitoring significance of WT1 gene level in the prognosis of acute myeloid leukemia (AML) patients with normal karyotype after hematopoietic stem cell transplantation (HSCT). Methods The clinical data of 115 AML patients with normal karyotype who were treated with HSCT from July 2009 to March 2017 in the First Affiliated Hospital of Soochow University were retrospectively analyzed. The dynamic detection of bone marrow WT1 gene was carried out by using reverse transcription_polymerase chain reaction (RT_PCR). According to the relative expression level median of WT1 gene before transplantation, the whole patients were divided into the two groups (
