Ameliorative Effects of Aquilaria malaccensis Leaves Aqueous Extract on Reproductive Toxicity Induced by Cyclophosphamide in Male Rats
- Author:
Redzuan Nul Hakim Abdul Razak
1
;
Faridah Ismail
2
;
Muhammad Lokman MD Isa
3
;
Azantee Yazmie Abdul Wahab
4
;
Hussin Muhammad
5
;
Roszaman Ramli
4
;
Raja Arif Shah Raja Ismail
4
Author Information
- Publication Type:Journal Article
- Keywords: antioxidants, Aquilaria malaccensis, cyclophosphamide, oxidative stress, reproductive toxicity
- From:Malaysian Journal of Medical Sciences 2019;26(1):44-57
- CountryMalaysia
- Language:English
- Abstract: Background: Cyclophosphamide (CP) is a widely used anti-neoplastic and immunosuppressive agent that is associated with adverse side effects including reproductive toxicity. Aquilaria malaccensis (AM) is a traditional medicinal plant which was reported to exhibit high anti-oxidant and free radical scavenging properties. The present study was aimed to evaluate the protective effects of AM leaves extract on sperm quality following toxic exposure to CP. Methods: Forty-eight male Sprague Dawley rats were allocated into eight groups of six rats (n = 6): control, CP only (200 mg kg−1), AM only (100 mg kg−1, 300 mg kg−1 and 500 mg kg−1) and CP + AM (100 mg kg−1, 300 mg kg−1 and 500 mg kg−1). Animals were sacrificed after 63 days of treatment and the sperm from the caudal epididymis was taken for sperm analysis. Results: The body and the reproductive organs weight, sperm count and motility did not differ between CP and other groups (P > 0.05). A significant increase (P < 0.05) in percentage of the dead and abnormal sperm were seen in the CP alone treated group compared to the control group. Co-administration of AM to the CP exposed rats significantly reduced the (P < 0.05) percentage of abnormal sperm as compared to the CP only group. Conclusion: Overall, the present results represent the potential of AM to protect against CP induced reproductive toxicity.
- Full text:3.2019my0760.pdf
