Early diagnostic value of urinary NGAL for postoperative acute kidney injury in patients with acute Stanford type A aortic dissection
- VernacularTitle:尿 NGAL 对急性 Stanford A 型主动脉夹层手术后急性肾损伤的早期诊断价值
- Author:
XUE Yinying
1
;
ZHANG Cui
1
;
NIU Yongsheng
1
;
SUN Fang
1
;
LI Jing
1
;
MU Xinwei
1
Author Information
1. Department of Intensive Care Unit, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, P.R.China
- Publication Type:Journal Article
- Keywords:
Neutrophil gelatinase-associated lipocalin (NGAL);
acute Stanford type A aortic dissection;
acute renal injury
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2019;26(11):1103-1106
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the early diagnostic value of urinary neutrophil gelatinase-associated lipocalin (NGAL) for acute kidney injury (AKI) after acute Stanford type A aortic dissection. Methods From January 2018 to December 2018, the clinical data of 50 patients who underwent open surgery for acute Stanford type A aortic dissection were analyzed in Nanjing First Hospital. Urine specimens were collected before and 2 hours after the aortic dissection surgery. Patients were divided into an AKI group (n=27) and a non-AKI group (n=23) according to the Kidney Disease Improving Global Outcomes criteria. Receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of urine NGAL. Results The incidence of postoperative AKI was 54.00% (27/50). There was a statistically significant difference between the two groups in serum creatinine concentration at 2 hours after surgery and urinary NGAL concentration before the surgery (P<0.05). The area under ROC curve of preoperative urinary NGAL concentration was 0.626. When cut-off value was 43 ng/mL, the sensitivity was 40.7%, specificity was 95.7%. The area under ROC curve of urinary NGAL concentration at 2 hours after surgery was 0.655, and when the cut-off value was 46.95 ng/mL, the sensitivity was 63.0%, specificity was 78.3%. Conclusion Urine NGAL can predict postoperative AKI in patients with acute Stanford type A aortic dissection, but its value is limited.
