The Influence of Atopic Findings on Severity of Pneumonia in Children with 2009 Pandemic Influenza A (H1N1) Infection.
- Author:
Jong Hee KIM
1
;
Hyun Jeong KIM
;
Im Ju KANG
Author Information
1. Department of Pediatrics, Fatima Hospital, Daegu, Korea.
- Publication Type:Original Article
- Keywords:
2009 Pandemic influenza A (H1N1);
Pneumonia;
Atopy;
Allergic disease
- MeSH:
Asthma;
Child;
Eosinophilia;
Humans;
Immunoglobulin E;
Influenza, Human;
Pandemics;
Pneumonia;
Polymerase Chain Reaction;
Retrospective Studies;
Rhinitis;
Rhinitis, Allergic, Perennial;
Risk Factors;
RNA-Directed DNA Polymerase
- From:Korean Journal of Pediatric Infectious Diseases
2011;18(2):182-192
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Atopic findings may be associated with severity of pneumonia in 2009 pandemic influenza A (H1N1) infection, which could suggest a possible association between atopic findings and the severity of viral infections. Thus, we studied association between atopic findings and severity of disease in children with H1N1 influenza infection. METHODS: A retrospective study was performed in 74 children admitted in a single tertiary institute and confirmed as H1N1 patients by reverse transcriptase (RT) - polymerase chain reaction (PCR). They were divided into 2 groups according to the severity of pneumonia. We evaluated whether the atopic finding is risk factor between the two groups. RESULTS: Children with severe pneumonia had higher percentages of serum eosinophilia (88% vs 40%, P<0.001), asthma (65% vs 35%, P=0.011), allergic rhinitis (71% vs 40%, P=0.009), and IgE level (P=0.007). We found positive correlations between aeroallergen sensitizations and severity of pneumonia (82% vs 53%, P=0.007). CONCLUSION: Among patients with H1N1 pneumonia, asthma and atopic findings are risk factors for severity of pneumonia.
