The efficacy and safety of Chai Hu Shu Gan San as an adjuvant drug for selective serotonin reuptake inhibitors in the treatment of post-stroke depression: A meta-analysis
- Author:
Chenglin Wang
1
;
Jiguo Gao
1
;
Beilin Zhang
1
;
Rensheng Zhang
1
;
Chao Wang
1
;
Xinyuan Li
1
;
Heqian Du
1
;
Chunkui Zhou
1
;
Shaokuan Fang
1
Author Information
- Publication Type:Journal Article
- Keywords: Chai Hu Shu Gan San; selective serotonin reuptake inhibitors; post-stroke depression; meta-analysis
- From:Neurology Asia 2019;24(3):215-227
- CountryMalaysia
- Language:English
- Abstract: Post-stroke depression often seriously affects the prognosis and quality of life of patients and many clinical trials had shown that Chai Hu Shu Gan San (柴胡疏肝散) combined with selective serotonin reuptake inhibitors (SSRIs) had good efficacy and minor side effects. We aimed to conduct this metaanalysis to evaluate the efficacy and safety of Chai Hu Shu Gan San as an adjuvant drug for SSRI in treating post-stroke depression. We searched PubMed, EMBASE, Cochrane Library, Wanfang, China Biology Medicine disc (CBM), Chongqing VIP, and CNKI (China National Knowledge Infrastructure) from their date of foundation to December 15, 2018. Literature screening, data extraction and quality assessment were conducted by two authors independently. The data synthesis and analysis were performed by using Review Manager (RevMan) 5.3 software and sensitivity analysis was conducted to assess the robustness of the results. Finally, a total of 22 articles were included. The meta-analysis confirmed the advantages of the combination of SSRI and Chai Hu Shu Gan San, mainly from four aspects: the Hamilton Depression (HAMD) scale score (MD=3.66; 95% DI=2.33-4.98; p<0.001), the Modified Edinburgh Scandinavian Stroke Scale (MESSS) score (MD=4.87; 95% CI=2.32-7.43; p<0.001), the efficacy rate (OR=3.50; 95% CI =2.61-4.69; p<0.001) and the incidence of adverse reactions (OR=0.28; 95% CI=0.17-0.46; p<0.001). No significant publication bias was observed, and sensitivity analysis suggested a good stability of the results. According to the present evidence, we concluded that Chai Hu Shu Gan Sa
- Full text:7.2019my00971.pdf
