A case of acetaminophen induced bronchial asthma without aspirin sensitivity.
- Author:
Sun Sin KIM
1
;
Soo Keol LEE
;
Dong Ho NAHM
;
Hae Sim PARK
Author Information
1. Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
- Publication Type:Case Report
- Keywords:
Acetaminophen-induced asthma;
oral provocation test
- MeSH:
Acetaminophen*;
Aspirin*;
Asthma*;
Dyspnea;
Hypersensitivity;
Prostaglandin-Endoperoxide Synthases;
Urticaria
- From:Journal of Asthma, Allergy and Clinical Immunology
2000;20(3):545-550
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Acetaminophen is a widely used analgesic-antipyretic. Hypersensitivity reactions to acetaminophen are rare and selective sensitivity to acetaminophen without aspirin or non-steroidal antiinflammatory drug intolerance is even rarer. We experienced a case of acetaminopheninduced bronchial asthma without aspirin sensitivity. An oral challenge test upto 650mg of Tylenol demonstrated urticaria and dyspnea with greater than 20% decrease of FEV1. Both oral provocation test with 500mg of aspirin and lysine-aspirin bronchoprovocation test showed negative results. In conclusion, we report a case of acetaminophen-induced asthma without aspirin sensitivity. Cyclo-oxygenase inhibition may not be a pathogenic mechanism of acetaminophen-induced bronchial asthma. Further studies will be needed to clarify the mechanism of this reaction.
