Research progress on the CD4 +T cell balance in oral cancer and precancerous diseases
- Author:
TIAN Yuanye
1
;
TANG Zhangui
1
Author Information
- Publication Type:Review
- Keywords: Th1; Th2; Th17; Regulatory T cell; Oral squamous cell carcinoma; Oral precancerous lesion
- From: Journal of Prevention and Treatment for Stomatological Diseases 2019;27(2):115-121
- CountryChina
- Language:Chinese
- Abstract: CD4 +T cells play an important role in regulating adaptive immune responses to various inflammatory responses. Parental T cell populations can differentiate in response to different cytokines into at least four subpopulations: Th1, Th2, Th17, and Treg cells. These differentiated T cells participate in various immune responses and have different roles and functions in oral cancer and precancerous diseases. The Th1/Th2 balance, the Th17/Treg balance and the occurrence and development of oral cancer and precancerous diseases are related to immune imbalances. Reversing these T cell imbalances and strengthening the patient’s autoimmune function may prevent or even reverse the progression of oral and precancerous diseases. This paper reviews the research advances on the CD4 +T cell balance in oral cancer and precancerous lesions.
- Full text:CD4 T细胞平衡在口腔癌及癌前病损中的研究进展.pdf
