The research progress of circRNA in the cardiovascular disease
10.7507/1007-4848.201812073
- VernacularTitle:环状 RNA 在心血管疾病中的研究进展
- Author:
LEI Kexin
1
,
2
;
BAI Hetian
1
,
2
;
LI Tao
3
;
QIAN Yongjun
3
Author Information
1. 1. Department of Cardiovascular Surgery and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, P.R.China
2. 2. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, P.R.China
3. Department of Cardiovascular Surgery and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, P.R.China
- Publication Type:Journal Article
- Keywords:
Circular RNA;
loop-forming mechanism;
biological function;
cardiovascular disease;
biomarker
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2019;26(10):1021-1025
- CountryChina
- Language:Chinese
-
Abstract:
Circular RNA (circRNA) is a non-coding RNA which exists widely in eukaryotic cells with a structure of covalently closed continuous loop. Its generation, characteristics and functions have received extensive attention, making it one of the hot spots in the field of non-coding RNA research. Many studies have found that circRNA plays an important role in the development of various diseases including cardiovascular disease, nervous system disease and cancer. Cardiovascular disease is a worldwide common disease with high incidence and poor prognosis. Its exact pathogenesis has not been found, which blocks the development of cardiovascular disease treatment. In this review, we summarize the loop-forming mechanisms, the functions and the progress of current researches of circRNA in cardiovascular diseases.
