Association of solute carrier family 2, member 9 (SLC2A9) genetic variant rs3733591 with gout in a Malay sample set
- Author:
Wan Rohani Wan Taib
- Collective Name:Wan Rohani Wan Taib, PhD1;Mahfudzah Adanan, MSc2;Nazihah Mohd Yunus, MPath2;Tan Huay Lin, PhD2;Wan Syamimee Wan Ghazali, MMed3 ;Amanda Jane Phipps-Green, MSc4;Tony Richard Merriman, PhD
- Publication Type:Journal Article
- Keywords:
gout;
SLC2A9;
Malay;
association;
SNPs
- From:
The Medical Journal of Malaysia
2018;73(5):307-310
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Gout is one of the most common inflammatory
arthritis in Malaysia. It is due to persistent hyperuricemia
that leads to the formation and deposition of intra- and periarticular monosodium urate crystals either due to excessive
production or insufficient excretion of uric acid. Incidence
and prevalence of gout is increasing worldwide, with a
higher rate among men compared to women. Malay is the
largest ethnic group in Malaysia, followed by Chinese and
Indian. SLC2A9 is a renal urate transporter that controls
renal uric acid excretion and genetic variants in SLC2A9 are
associated with the risk of gout in several populations. This
study aimed to test if the SLC2A9 variant (R265H, rs3733591)
is also associated with gout among Malays in Malaysia.
Methodology: A total of 89 patients with gouty arthritis and
100 normal subjects who consented and were recruited in
this study. The serum urate and creatinine were measured.
The SNP genotyping was performed using PCR-RFLP
method for rs3733591 and BST 1236 was used as a
restriction enzyme to cut the targeted amplicons.
Result: SLC2A9 variant was associated with gout, p-value of
0.007, OR=4.713 [95%CI 1.530-14.513], however this
association was not significant after adjustment for age and
gender with p=0.465 (OR=1.950; 95%CI[0.325-11.718]).
Conclusion: Our data suggest that the genetic variant of
SLC2A9 may contribute to the susceptibility of gout among
Malays in Malaysia.
- Full text:6.2018my1331.pdf
