Research progress on the function and metabolism of d-alanine in bacteria
10.12016/j.issn.2096-1456.2019.04.012
- Author:
GUO Xiao
1
,
2
;
DU Xinmei
1
,
2
;
CHENG Lei
1
,
2
;
ZHOU Xuedong
1
,
2
;
LI Mingyun
1
,
2
Author Information
1. State Key Laboratory of Oral Diseases &
2. National Clinical Research Center for Oral Diseases, West China Stomatology Hospital of Sichuan University
- Publication Type:Review
- Keywords:
D-alanine;
Bacteria;
Function;
Metabolism;
Dental caries;
Targeted therapy
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2019;27(4):264-267
- CountryChina
- Language:Chinese
-
Abstract:
D-alanine is a chiral molecule of L-alanine that participates in the formation and regulation of cell wall peptidoglycans, phosphoteichoic acid, spore germination and respiratory metabolism in individual bacteria. D-alanine participates in the formation and regulation of biofilm in bacterial communities. The function and metabolism of D-alanine in bacteria are specific, and the enzymes and genes in its metabolic pathway can be used as drug targeting sites. In this paper, the synthesis, metabolism and function of D-alanine in bacteria were reviewed, and the relationship between D-alanine and pathogenicity of Streptococcus mutans was discussed to provide a theoretical basis for candidate targeting sites of anti-caries drugs. According to existing research results, the enzymes and related genes involved in D-alanine metabolism play important roles in the growth and biofilm formation of Streptococcus mutans, and D-alanine is expected to be a target for the design of anti-caries drugs.
- Full text:D-丙氨酸在细菌中的功能和代谢研究进展.pdf
