Effects of low-carbohydrate diet and resistance exercise training on physical characteristics and concentrations of plasma metabolites and hormones

Sho Ito; Yasuaki Karasawa; Daisuke Hoshino; Masashi Fujii; Miki Eto; Junya Tsuru; Chieko Kashiwado; Shinya Kuroda

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Effects of low-carbohydrate diet and resistance exercise training on physical characteristics and concentrations of plasma metabolites and hormones

VernacularTitle:低糖質食事法およびレジスタンス運動が身体組成と血中代謝物・ホルモン濃度に与える影響
Author: Sho ITO ¹ ; Yasuaki KARASAWA ² ; Daisuke HOSHINO ² ; Masashi FUJII ² ; Miki ETO ³ ; Junya TSURU ² ; Chieko KASHIWADO ⁴ ; Shinya KURODA ⁴
Author Information

1. Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo
2. Department of Biological Sciences, Graduate School of Science, University of Tokyo
3. Molecular Genetic Research Laboratory, Graduate School of Science, University of Tokyo
4. RIZAP, Inc.
Keywords: low-carbohydrate diet; resistance exercise training; physical characteristics; plasma metabolites; blood hormones
From:Japanese Journal of Physical Fitness and Sports Medicine 2019;68(3):223-227
CountryJapan
Language:Japanese
Abstract: We clarify the effect of combination of low-carbohydrate diet and resistance exercise training on physical characteristics and plasma concentrations of metabolites and hormones in humans. Intervention of low-carbohydrate diet and resistance exercise training were performed on 7 healthy men and 3 women (age 39.6 ± 7.0 year; BMI 25.1 ± 3.6 kg/m2) for 8 - 12 weeks. Physical characteristics and 106 test items including and blood concentrations of metabolites and hormones were measured before and after the intervention. The effects of intervention were analyzed by a paired t-test, in which multiple testing was corrected by the method of Storey (significant variation q <0.1). In both men and women, carbohydrate and energy intake per day were low, and protein intake per day was almost the same as the recommended dietary allowance. Because carbohydrate intake were limited (174 kcal), resulting in reduction of total energy (1186 kcal). After the intervention, body weight, BMI (Body Mass Index), fat mass, body fat, muscle mass and body water content significantly decreased, while muscle mass per body mass significantly increased. Glycine, 3-methyl histidine, inorganic phosphorous, urea nitrogen, urea nitrogen per creatinine, were significantly increased, while HbA1c, white blood cell count, β-aminoisobutyric acid, adrenalin, free T4, blood ammonia, γGTP, cholinesterase, and leptin were decreased.