Clinical Trial on the Hypotensive Effect of Arotinolol(S-596) in Essential Hypertension.
10.4070/kcj.1989.19.2.325
- Author:
Chung S LEE
;
Jung E KIM
;
Hyun C JANG
;
Sung K PARK
;
Sung K KANG
- Publication Type:Clinical Trial ; Original Article
- Keywords:
Arotinol;
Hypertension
- MeSH:
Blood Pressure;
Diarrhea;
Dizziness;
Electrocardiography;
Electrolytes;
Headache;
Humans;
Hypertension*;
Urinalysis
- From:Korean Circulation Journal
1989;19(2):325-331
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Arotinolol was administered orally to 31 patients to evaluate is antihypertensive action. After one week of antihypertensive medication, they were given Arotinolol 30mg daily for 4 week. Routine serum chemistries, electrolytes, urinalysis and electrocardiography were studied before and after Arotinolol. Blood pressure measured in sitting, supine and standing position was 175.3+/-5.4/115.7+/-4.0, 168.0+/-5.2/150.0+/-3.8, 154.4+/-8.5/103.4+/-3.2mmHg in control and 143.8+/-2.8/93.3+/-2.8, 144.6+/-5.4/88.1+/-4.3, 139.7+/-4.6/86.8+/-3.4mmHg in Arotinolol treatment group. The differences between both blood pressure were statistically significant(P<0.01). No laboratory test showed significant difference between both period. There were no significant side effects except 2 cases of transient headache and dizziness respectively, and one case of diarrhea. In summary, Arotinolol apears to reduce blood pressure effectively with minimal side effects.
