Appropriateness of Proton Pump Inhibitors Prescription in Patients Admitted to a Malaysian Tertiary Hospital
- Author:
Then Ru Fah
1
Author Information
1. Medical Department, Serdang Hospital, Malaysia.
- Collective Name:Then Ru Fah; Tan Yi Jun; Pan Yan and Chieng JinYu
- Publication Type:Journal Article
- Keywords:
Proton pump inhibitor;
Overutilization;
Appropriateness.
- From:International Journal of Public Health Research
2019;9(1):1043-1050
- CountryMalaysia
- Language:English
-
Abstract:
Introduction Proton pump inhibitors (PPIs) are one of the commonest drug prescribed,
however it is not without risk of adverse effects especially if the usage is
inappropriate. We aimed to evaluate the frequency, indications and
appropriateness of PPIs prescription among the medical inpatients, Serdang
Hospital, which is a tertiary hospital in Malaysia.
Methods This is a cross sectional study consisting of 1184 patients admitted to medical
ward and received PPI from 1st July 2016 to 31st March 2017, and their
database were further analysed by SPSS Statistics 17.0. Unpaired t-test was
performed to analyze the data collected. P < 0.05 (two-tailed) is considered
significant. Their indications were cross-referenced against the indications
adapted from the United States Food and Drug Administration (FDA).
Results About 23.9% (1184/4953) of inpatients were using PPIs, and 63.0%
(746/1184) of them recently started on PPI in the ward, with mean age of 59.7
years. More male patients were commenced on PPIs during hospitalization (P
value < 0.05). Based on the FDA guideline, only 21.8% patients were
indicated, 32.2% were borderline indicated, and 46.0% patients were not
indicated in prescribing PPIs. Stress ulcer prophylaxis was the commonest
indication, while anaemia with no evidence of gastrointestinal bleed was the
main non-indication in starting PPIs. Only 11% of patients had performed the
oesophago-gastro-duodenoscopy (OGDS) during the hospital stay.
Conclusions 46.0% of inpatients were inappropriately prescribed PPIs according to FDA
guideline. More efforts should be initiated to improve the current situation of
PPIs overutilization in Malaysia.
- Full text:21.2019my0220.pdf
