Advances in epigenetic changes induced by pathogenic factors of oral diseases
10.12016/j.issn.2096-1456.2019.06.012
- Author:
REN Yushu
1
;
LIN Xiaoping
1
Author Information
1. Department of Stomatology, Affiliated Shengjing Hospital of China Medical University
- Publication Type:Review
- Keywords:
Epigenetics;
Bacteriology;
Oral diseases;
Oral health;
Etiological factor
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2019;27(6):400-403
- CountryChina
- Language:Chinese
-
Abstract:
The oral cavity is a complex and complete ecosystem. In addition to the microbial community, anatomical structure, temperature, humidity, pH, nutrient sources, proteases, and external factors all influence the ecosystem. Under normal circumstances, this ecosystem maintains a dynamic balance with the host. However, due to the large number of influencing factors, this dynamic balance is fragile. Abnormal changes in a certain factor can disrupt this balance and cause oral cavity disease. Increasing studies have confirmed the role of genetic factors in the etiology of oral diseases. With the understanding of the pathogenesis of oral diseases, the pathogenic factors induced by oral diseases have attracted more attention. This article reviews the key role of epigenetic changes induced by pathogenic factors, such as bacteria, viruses, and cytokines, in the pathogenesis of oral diseases and contributes to the development and application of related drugs.
- Full text:口腔疾病致病因素诱导表观遗传改变研究进展.pdf
