A Case-Control Study and Meta-Analysis of the Association of eNOS rs1799983 SNP with Stroke Risk
- Author:
Phneh Ky
1
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2
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3
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4
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5
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6
Author Information
1. Biotechnology Programme
2. Faculty of Science and Natural Resources
3. Universiti Malaysia Sabah
4. Jalan UMS
5. 88400 Kota Kinabalu
6. Sabah.
- Collective Name:PHNEH KY; CHONG ETJ; SYBIL SHAH S; CHIA YK; AG. DAUD DM; JALIL E; CHENG KCS; LEE PC;
- Publication Type:Journal Article
- Keywords:
eNOS;
meta-analysis;
rs1799983;
single nucleotide polymorphism;
stroke
- From:Medicine and Health
2019;14(1):118-134
- CountryMalaysia
- Language:English
-
Abstract:
The endothelial nitric oxide synthase (eNOS) rs1799983 polymorphism is known to
increase the risk towards stroke, but data is under-reported in Malaysian population.
Therefore, this study sought to investigate this association in a Malaysian population
and in a comprehensive meta-analysis. Genotyping of the eNOS rs1799983
polymorphism was performed for 241 Malaysians using a hydrolysis probe. Odd
ratio with 95% confidence interval was calculated. Meta-analysis was conducted
using the Comprehensive Meta-Analysis software ver. 2.2.064. A p-value less than
0.05 was considered statistically significant. Overall, our results showed that the
presence of eNOS rs1799983-T allele increases the risk towards stroke, particularly
in males, fast-food goers and Malaysian Chinese. The meta-analysis showed that
the rs1799983 polymorphism is significantly associated with an increase ischemic
stroke risk in the recessive and allelic models. After stratified with population, these
associations remain significant in the Asian population but not in the Caucasian
population. In summary, this study establishes a significant relationship between
the eNOS rs1799983 polymorphism with gender, lifestyle and ethnicity differences
towards stroke risk in the Malaysian population. In addition, our meta-analysis
suggests that the eNOS rs1799983 polymorphism is associated with an increase
risk of ischemic stroke.
- Full text:12.2019my0100.pdf
