Donors’ Calcium Level and Bone Density after Frequent and Regular Plateletpheresis Blood Donation
- Author:
Nor Hafidza Haron
1
Author Information
1. Unit Perubatan Transfusi, Hospital Tengku Ampuan Rahimah, Jalan Langat, 41200 Klang, Selangor, Malaysia
- Collective Name:Nor Hafidza Haron; Bakiah Shaharuddin; Faraizah Abd Karim; Narazah Mohd Yusoff
- Publication Type:Journal Article
- Keywords:
Plateletpheresis;
National Blood Centre;
Dual emission X-ray absorptiometry;
Magnesium and calcium;
Bone density
- MeSH:
Bone density
- From:Malaysian Journal of Medicine and Health Sciences
2018;14(Supplement 1):7-10
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Citrate is commonly used as an anti¬coagulant during plateletpheresis procedure. The calcium chelating property of citrate may cause hypocalcaemia when the anticoagulated blood are returned to the donor’s circulation after selective removal of platelet. This study aims at investigating how regular plateletpheresis affects calcium level and bone density in the donors. Methods: A cross-sectional study was conducted among healthy donors at National Blood Centre, Kuala Lumpur, from 15th January till 31st March 2016. Donors were divided into two groups based on the frequency of plateletpheresis donation: low frequency group - donors who had donated less than 20 times, high frequency group - donors who had donated more than 50 times. Dual emission X-ray absorptiometry (DEXA) scan was performed to assess bone density. Pre-donation blood sampling was taken for albumin level. Calcium and magnesium levels were measured before and after donation. Results: Fifty donors participated in this study where the median age of participants was 35.0 years for low frequency and 45.2 years for high frequency group. There was no significant difference in the corrected calcium for both groups before and after plateletpheresis. However, the magnesium levels were significantly reduced in both arms (P<0.05). The albumin level and DEXA scan showed no significant differences between the groups. Conclusion: This study did not show any significant difference in calcium levels, albumin and bone density; but donors’ magnesium levels were reduced in low and high frequency donors after plateletpheresis.
- Full text:11.2018my0306.pdf
