Expression of NF-κB in oral squamous cell carcinoma and paracancerous tissues and its significance
10.12016/j.issn.2096-1456.2019.06.004
- Author:
GUI Xinwei
1
;
YAO Xiaowu
1
;
CHEN Shisheng
1
;
LU Zizheng
1
;
LIN Minxiao
1
;
PENG Yu
1
Author Information
1. Department of Stomatology, The Second Affiliated Hospital , Medical College of Shantou University
- Publication Type:Journal Article
- Keywords:
Oral neoplasms;
Carcinoma;
squamous cell;
paracancerous tissues;
NF-κB
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2019;27(6):360-363
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression and significance of NF-κB in oral squamous cell carcinoma and paracancerous tissues.
Methods: Cancerous and paracancerous tissues about 5 mm outside the tumor boundary were cut from 47 patients with OSCC. NF-κB expression in these tissues were detected by the immunohistochemical SP method and compared with that in 32 normal oral mucosa tissues.
Results : The average optical density (OD value) of immunohistochemical-positive cells in cancer tissues and paracancerous tissues was higher than that in normal tissues, and the difference was statistically significant (P < 0.001). There was no significant difference in the OD values between cancer tissues and paracancerous tissues (P=0.356). The rate of NF-κB positive expression in cancer tissue and paracancerous tissue was significantly higher than that in normal mucosa tissue, and the difference was statistically significant (P < 0.001). There was no significant difference in the rate of NF-κB positive expression between cancer tissues and paracancerous tissues (P=0.117), but the rate of moderate-to-strong positive expression in cancer tissues was significantly higher than that in paracancerous tissues (P < 0.001).
Conclusion: NF-κB may be involved in the development of OSCC.
- Full text:NF-κB在口腔鳞状细胞癌及癌旁组织中的表达意义.pdf
