Mechanisms of scar formation and research progress in anti-fibrosis therapy after glaucoma filtration surgery
10.3980/j.issn.1672-5123.2019.10.12
- VernacularTitle:青光眼滤过术后瘢痕形成机制及抗瘢痕化研究进展
- Author:
Ya-Nan Kong
1
Author Information
1. Department of Ophthalmology,the Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China
- Publication Type:Journal Article
- Keywords:
glaucoma filtration surgery;
filtering channel;
anti-scarring treatment
- From:
International Eye Science
2019;19(10):1688-1691
- CountryChina
- Language:Chinese
-
Abstract:
Filtering channels carring and subsequent obstruction are the main cause of operation failure after glaucoma filtration surgery. During the process of scarring, human Tenon fibroblasts are transformed into myofibroblasts and secrete a large amount of extracellular matrixproteins. The derangement of the collagen fiber is also observed. A large number of studies have been carried out by domestic and foreign researchers on the treatment of postoperative filtering channel scarring. In this review we summarize the mechanisms of scar formation after glaucoma filtration surgery and corresponding research progress in recent years.
- Full text:201910012.pdf
